Recombinant human interferon gamma, consists of , and deprived of the first three. about. , replaced on Met. The molecular weight of . Microbially synthesis in recombinant Escherichia coli strain and purified by column chromatography. The specific antiviral activity proviron steroid on cells (human fibroblasts) infected with vesicular stomatitis virus is units per mg protein.
The receptors of interferon gamma are macrophages, neutrophils, natural killer cells, cytotoxic T-lymphocytes. Interferon gamma activates the effector functions of these cells, in particular their mikrobotsidnost, cytotoxicity, cytokine production, and nitroxide superoxide radicals, thereby causing the death of intracellular parasites. Interferon gamma inhibits Activates production of acute phase proteins, inflammation, enhances gene expression of components proviron steroid of the complement system.
Unlike other interferons increase expression of antigens by MHC as the I-st and the II-th classes in different cells, and induces the expression of these molecules, even those cells that do not express them constitutively. This increases the efficiency of antigen presentation and the ability of their recognition by T lymphocytes. Interferon proviron steroid gamma blocking viral DNA replication and RNA synthesis of viral proteins and assembly of mature virus particles. Interferon gamma has a cytotoxic effect on the virus-infected cells.
Interferon Gamma blocks the synthesis of ß-TGF, responsible for the development of pulmonary fibrosis and liver.
Treatment of chronic hepatitis C, chronic hepatitis B, HIV / AIDS infection and pulmonary tuberculosis in combination therapy.
Prevention of infectious complications in patients with chronic granulomatous disease.
The treatment of cancer in combination therapy as an immunomodulator, including in combination with chemotherapy.
Treatment of genital herpes infection and shingles (herpes zoster) in monotherapy.
Treatment of urogenital chlamydiosis proviron steroid in complex therapy.
Individual intolerance to interferon gamma, or any other component of the drug. Pregnancy. Autoimmune disease. Diabetes.
Dosing and Administration
The introduction of the drug intramuscularly or subcutaneously.
The contents of the vial is dissolved in 2 ml of water for injection.
The dose is determined individually.
For the treatment of patients with chronic viral hepatitis B, chronic hepatitis C, and HIV / AIDS infection and pulmonary tuberculosis average daily intake for adults is 500 000 ME. Introduced 1 time a day, every day or every other day. The course of treatment is from 1 to 3 months, if necessary, after 1-2 months, repeat the treatment.
For the prevention of infectious complications in patients with chronic granulomatous disease usually mean daily dose for adults is the ME 500000. Introduced 1 time a day, every proviron steroid day or every other day. In the course of 5-15 injections, if necessary, extend or repeat the course in 10-14 days.
For the treatment of cancer, the mean daily dose for adults is the ME 500000. We introduce the 1 times a day every other day.
For the treatment of genital herpes virus infection, shingles (herpes zoster) and urogenital chlamydiosis average daily dose for adults is the ME 500000. Introduced 1 time per day subcutaneously every other day. The course of treatment is 5 injections.
Local pain at the site of subcutaneous injection in the form of mild pain bursting nature (similar to overtrain the muscle) and flushing.
The use of high doses of more than 1,000,000 ME may be accompanied by the development of a flu-like syndrome: headache, weakness, fever, pain in the joints. Mild symptoms do not require pharmacological correction. When expressed phenomena – relief using paracetamol.
Valium for drug of a solution for intramuscular or subcutaneous injection in vials of 100,000 ME, 500000 ME, ME 1000000 or 2000000 ME active ingredient per 1 vial. 1, 5, 10 or 20 vials proviron steroid of drug with instructions for use placed in a pile of cardboard, or at 1, 5, 10 or 20 vials of drug in blisters or cassette contour packaged with instructions for use placed in a pile of cardboard.
In a dry place, protected from light and the reach of children, at a temperature of 2-10 ° C. Do not freeze
2 years. Do not use after the expiration date.
Terms of pharmacies holiday
Dispensed by prescription.