loperamide binding to opioid receptors in the intestinal wall and inhibits acetylcholine release of prostaglandins, thereby reducing the increasing motility and transit time through proviron side effects the intestine contents. It improves the tone of the anal sphincter, thereby reducing incontinence of stool and the urge to defecate,tablets for sucking bioequivalent Imodium capsules and tablets with a film coating. Subjected to intensive metabolism in the process of oxidative N-demethylation in the “first” passage through the liver.
Write mainly through the gastrointestinal tract with feces, a small portion excreted in the urine (in the form of conjugated metabolites).
- acute and chronic diarrhea
- regulation of the chair in patients with iliostomaContraindications
- children’s age (up to 6 years);
- hypersensitivity to loperamide and / or other components of the drug;
- acute dysentery and other infections of the gastrointestinal tract (caused, including Salmonella, Shigella and Campylobacter);
- ileus (including avoided peristalsis suppression if necessary), diverticulosis, acute ulcerative colitis or pseudomembranous enterocolitis (diarrhea caused by taking antibiotics);
- first trimester of pregnancy
- with hepatic insufficiencyPregnancy and lactation
Although there is no indication of teratogenic or embryotoxic effects, Imodium during pregnancy can be proviron side effects given only if the expected benefit of therapy to the mother outweighs the potential risk to the fetus.During the first trimester of pregnancy is contraindicated receive Imodium. Since small amounts of the drug can penetrate into breast milk intake lozenge during breast feeding is contraindicated.
Dosing and Administration
Inside. The tablet is placed on the tongue for a few seconds, it dissolves, after which it is swallowed with the saliva without drinking water.
Adults, including the elderly, and children over 6 years: Acute diarrhea: the initial dose – 2 tablets (4 mg) for adults 1 tablet (2 mg) for children, after taking 1 tablet (2 mg) after each defecation in the case of liquid stool. Chronic diarrhea: the initial dose – 2 tablets (4 mg) per day for adults and one tablet (2 mg) for children; more usually, this dose is individually adjusted so that the stool frequency was 1-2 times per day, which is usually achieved with a maintenance dose of 1 to 6 tablets per day.
. The maximum daily dose for acute and chronic diarrhea in adults – 8 tablets (16 mg); children maximum daily dose is calculated on the basis of body weight (3 tablets per 20 kg body weight of the child – 8 tablets (16 mg)).
When a normal chair or stool in the absence of the drug over 12 hours overturned.
- allergic reactions (skin rash);
- constipation and / or bloating;
- intestinal colic;
- retention of urine (rare);
- ileus (very rare);
- pain or discomfort in the abdomen;
- nausea, vomiting;
- drowsiness, dizziness;
- dry mouth;
- burning sensation or tingling tongue, occurs immediately after taking the tablets for sucking.Overdose
depression of the central nervous system (CNS): stupor, incoordination, drowsiness, cramps, increased muscle tone, respiratory depression; ileus. Children are more sensitive to the effects on the CNS.
Treatment is symptomatic: gastric proviron side effects lavage, activated charcoal (not later than 3 hours after taking Imodium), mechanical ventilation. The antidote – naloxone. Since the duration of action of Imodium more than the naloxone (1-3 hours), you may need to re-appointment of the latter. To detect possible CNS depression the patient should be monitored closely for at least 48 hours.
Interactions with other drugs not mentioned.
As lozenges are quite fragile, to avoid damage to them can not push through the foil. In order to get the pill from the blister is necessary to take the foil over the edge, completely remove it from the wells in which the tablet and gently push the bottom, remove the tablet from the packaging.
The drug should be discontinued immediately if developing constipation or bloating.
Because the treatment of diarrhea Imodium is only symptomatic, it is necessary, along with, possibly, means to apply etiotropic. Patients with diarrhea, especially among children, and may appear hypovolemia reduction electrolyte content. In such cases, the most important is the replacement therapy to replenish fluids and electrolytes.
In acute diarrhea, if 48 hours is not observed clinical improvement, taking Imodium should stop and eliminate infectious genesis of diarrhea.
Do not use for diarrhea accompanied by blood in stool and high temperature.
In patients with AIDS, treatment should be discontinued immediately at the first signs of bloating. In some cases in AIDS patients with infectious colitis both viral and bacterial origin in the treatment Imodium may develop toxic expansion of the colon.
Patients with hepatic impairment should be monitored carefully for signs of toxic damage.
During treatment, it is recommended to diet and fluid replacement .
The impact of the drug on the ability to drive and control technology
in the period of treatment should refrain from driving and transport activities potentially hazardous activities that require high concentration and psychomotor speed reactions.
1 or 2 blisters of aluminum / aluminum containing 10 tablets in a carton box with instruction on the medical application.
At a temperature of 15 to 30 ° C out of proviron side effects reach of children.
Conditions of supply of pharmacies
without a prescription.
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