Opioid receptors in the intestinal wall, resulting in inhibition of propulsive motility, increase intestinal transit time and increased resorption of water and electrolytes. Loperamide does not change the physiological intestinal microflora and increases the tone of the anal sphincter. Imodium Plus does not have a central action. Simethicone is not absorbed in the intestine, and proviron for women loperamide soaked, subjected to intensive metabolism in the liver after the first pass. As a result, the systemic circulation gets very little loperamide.
Simethicone is an inert surface-active compound having defoaming properties, and therefore alleviates the symptoms associated with diarrhea, particularly flatulence, abdominal discomfort and cramping. In humans, the half-life averages loperamide 10.8 h, ranging from 9 to 14 hours. Loperamide is well absorbed from the intestine, but almost completely metabolized in the liver and then excreted with the bile in the form of conjugated metabolites. Due to the intensive first-pass metabolism in the plasma contains very low concentrations of the unchanged loperamide. The metabolites are excreted mainly with loperamide feces. Simethicone is generally not absorbed from the gastrointestinal tract.
Indications for use:
Imodium Plus is indicated for diarrhea of any etiology and its attendant symptoms. Recent often caused proviron for women by intestinal gas and neothozhdeniem include abdominal discomfort, cramping and flatulence.
Dosage and administration:
Adults and children over 12 years of age:
Initially, 2 tablets, then 1 tablet after each loose stool. At night you can not use more than 4 tablets, the length of taking the pills should not exceed 2 days. Use in Pediatrics: Imodium Plus is not recommended for children under 12 years of age. Use in elderly patients in the treatment of elderly patients dose adjustment is necessary. Use in patients with impaired function liver and kidneys: In patients with impaired renal function there is no need to reduce the dose of Imodium Plus. Imodium Plus should be used with caution in patients with severely impaired hepatic function, as they have slowed down the metabolism of the first pass.
Loperamide has long been widely used in clinical practice and does not cause serious side effects even with proviron for women prolonged use. In rare cases it reported hypersensitivity reactions (skin rash, and urticaria), and in extremely rare cases, anaphylactic shock and bullous rash, including toxic epidermal necrolysis. In most cases these patients received concomitant medications that may also cause or contribute to the development of allergic reactions. Also reported the occurrence of constipation and / or bloating. loperamide treatment is very rarely accompanied by the occurrence of paralytic ileus, and the side effect was observed mainly in patients who do not comply with the order prescribed by a doctor taking the drug, containing loperamide. It should be emphasized that symptoms such as abdominal pain / abdominal discomfort, nausea, vomiting, fatigue, drowsiness, dizziness, dry mouth, rarely occur while taking loperamide, typical of acute diarrheal syndrome. Therefore, usually quite difficult to establish a causal relationship between taking loperamide and the emergence of these symptoms.
Imodium Plus should not be administered to children under 12 years of age and in patients with hypersensitivity (allergy) to any ingredient of the drug.
Imodium Plus should not be used as monotherapy in acute dysentery, which is characterized by bloody diarrhea, or fever.
Imodium Plus should not be administered to patients with acute ulcerative colitis or pseudomembranous colitis associated with the treatment of broad-spectrum antibiotics.
Warnings and Precautions:
Since treatment of diarrhea with loperamide and simethicone is symptomatic, it is also necessary to carry out, whenever possible, therapy aimed at eliminating the causes of diarrhea. In patients with severe diarrhea may occur loss of fluid and electrolytes. In such cases it is necessary to carry out the appropriate replacement therapy (receiving fluids and electrolytes).
If there is no clinical improvement within 48 hours taking the pill Imodium Plus must be discontinued. Patients should be informed that in such a situation, they should consult a doctor.
Patients with severe hepatic impairment proviron for women should take Imodium Plus under the supervision of a physician.
In general, Imodium Plus should not be used in those cases when it is necessary to avoid the oppression of peristalsis; in case of constipation and / or bloating in the treatment Imodium Plus acceptance of this drug should be immediately discontinued.
Interaction with other drugs and other forms of interaction
Except drugs having similar pharmacological activity, interactions with other drugs is not detected.
Pregnancy and lactation Use during pregnancy by Currently there is no evidence that loperamide or simethicone have teratogenic or embryotoxic effect. Imodium Plus, as well as other drugs that can be taken during pregnancy, especially during the first trimester only if there is a compelling clinical indications. Use during lactation Small amounts of loperamide may enter the breast milk of women, and therefore Imodium Plus is not recommended during breast feeding.
Effect on driving and work with potentially dangerous machinery
Imodium Plus does not affect the speed of mental and physical reactions, and therefore unlikely to have a negative effect on driving a car or operating potentially dangerous machinery. However, patients who experience tiredness, dizziness or drowsiness should refrain from driving and working with potentially dangerous machinery.
Overdose Symptoms In case of overdose (including relative overdose due to hepatic dysfunction) may occur central nervous system depression (stupor, coordination disturbances, drowsiness, cramps, increased muscle tone, respiratory depression) and paralytic ileus. Children CNS depression may occur more frequently than in adults. Treatment If you have symptoms of an overdose the patient proviron for women should be entered as an antidote naloxone. Since loperamide lasts longer than naloxone (1 to 3 hours) may require repeated administration of naloxone. To detect possible CNS depression of the patient should be closely monitored for at least 48 hours.
Packages containing 6 or 12 tablets
At a temperature of 15 to 30 ° C out of reach of children.
Do not use after the expiration date.