Drug has immunoregulatory, detoxification, hepatoprotective effect and causes inactivation of free radical and peroxide compounds. Mode of action is based on three main effects: correction of the immune system, restoring the balance of oxidation-antioxidant response of the organism and inhibition of multidrug resistance mediated transmembrane transport proteins cell pump.The drug begins proviron bayer to develop for is manifested primarily detoxifying effect – enhanced antioxidant protection of the body by stimulating the production of ceruloplasmin, lactoferrin, catalase activity; preparation normalizes lipid peroxidation inhibits disintegration of the cell membrane phospholipids and the synthesis of arachidonic acid with subsequent reduction of blood cholesterol and the production of inflammation mediators. When toxic and infectious liver disease drug prevents cytolysis, reduces the activity of transaminases and bilirubin levels in blood serum.During the middle phase ( is amplified reactions phagocytosis and intracellular destruction of bacteria and viruses. During this period, there is normalization of immuno-regulatory code, there is an increase of production of specific antibodies. Imunofan Effect on the production of specific antiviral and antibacterial antibodies equivalent to the action of some therapeutic vaccines. Unlike the latter drug has no significant effect on the production of IgE antibodies reaginic class and does not increase the reaction of immediate type hypersensitivity;Imunofan stimulates the production of IgA in its congenital deficiency.
Imunofan effectively inhibits multidrug resistance of tumor cells and increases their sensitivity to cytostatic drugs.
Indications for use Applied in adults and children over 2 years of age for the prevention and treatment of immune deficiency and toxic conditions of acute and chronic infectious and inflammatory diseases.
Contraindications. Hypersensitivity, children up to 2 years.
Method of application and recommended dosage. Intranasal. When using the bottle should be kept upright, spray upward. Remove the protective cap from the spray. Before first use, fill the dosing pump by pressing the wide rim of the sprayer 3-4 times.Insert sprayer nostril with the head upright. Momentary push wide rim sprayer until it stops. One dose of the preparation contains 50 micrograms imunofana. The daily dose should not exceed 200 mg.
In the treatment of acute and chronic infectious and inflammatory diseases associated with symptoms of proviron bayer intoxication and immunodeficiency, imunofan appoint 1 dose (50 mcg) in each nostril 2 times a day, every day for 10 – 15 days. When opportunistic infections (cytomegalovirus, and herpes infection, toxoplasmosis, chlamydia, pneumocystis, cryptosporidiosis):
- 1 dose (50 mg) in each nostril two times a day, daily treatment 10 – 15 days. If necessary, you can repeat the course in 2-4 weeks.
In chronic viral hepatitis and chronic brucellosis:
- 1 dose (50 mcg) in each nostril 1 times a day, every day, a course of treatment 10 – 15 days to prevent recurrence should be repeated courses within 4 – 6 months.
In the scheme of treatment of patients with HIV infection:
- 1 dose (50 mg) in each nostril once a day 1, daily for 10-15 days. If necessary, you can repeat the course in 2-4 weeks.
In the treatment of cancer patients in the scheme of radical combined treatment (chemotherapy, radiotherapy and surgery):
- 1 dose (50 mg) in each nostril once a day 1, daily for 8-10 days prior to chemo-radiation therapy and surgery, followed by continuation of the course for the entire treatment period.
In patients with advanced neoplastic process (III – IV stage) of different localization in terms of the complex or symptomatic therapy:
- 1 dose (50 mg) in each nostril once a day 1, daily for 8-10 days.
If necessary, and there are significant phenomena of toxicity it is recommended repeat the course.
Side effects. The individual intolerance.
Caution. As a result, activation of phagocytosis proviron bayer possible short-term aggravation of foci of chronic inflammation, supported by persistent viral or bacterial antigens.
. Interaction with other drugs increases the effectiveness of other types of drug therapy: the use of imunofana helps to overcome resistance to glucocorticosteroid therapy. Purpose imunofana optionally in combination with steroidal and nonsteroidal antiinflammatory drugs.
Special instructions. Due to lack of knowledge should be used with caution during pregnancy and lactation.
Product form. Imunofan®, metered nasal spray 50 mcg / dose. 40 doses in plastic bottles with a capacity of 10 ml. The vials were sealed lid fitted with a metering pump with plastic housing, nozzle and protective cap or similar dispensing device. One vial together with instructions for use placed in a pile of cardboard.
Shelf life. 2 years. Do not use the drug after the expiry date stated on the package.
Storage conditions. In the dark place at a temperature of 2 ° C to 10 ° C, out of reach of children.