It has antiviral action and is effective against influenza viruses types A and B, adenovirus infection. In the experiment, in vitro and in vivo to effectively inhibit cytopathic effect and reproduction of influenza viruses types A and B, adenovirus. The antiviral buy proviron mechanism of action – inhibition of viral replication in the nuclear stage, delayed migration of newly synthesized viral from the cytoplasm to the nucleus. It has a modulating effect on the functional activity of the interferon system: causes an increase in blood interferon to the physiological norm, stimulates and normalizes reduced as interferon-producing ability of white blood cells, it stimulates gamma-interferon-producing ability of white blood cells. It causes generation of cytotoxic lymphocytes, and increases the content of cells having a high killer activity against transformed cells and viruses pronounced antiviral activity. The anti-inflammatory effect is due to inhibition of the production of key proinflammatory cytokines, decrease buy proviron miepoperoksidazy activity. The therapeutic efficacy of the flu appears in the shortened period pihoradki, reduction of intoxication (headache, weakness, dizziness), catarrhal symptoms, reducing the number of complications and duration of the disease in general.
The conducted toxicological studies indicate low toxicity and high safety profile of the drug . It was found that the drug is not mutagenic and carcinogenic, does not affect reproductive function does not have immunotoxic and allergenic properties, has no local irritating action.
The determination of the recommended doses of the drug in the blood plasma of available techniques is not possible. In an experiment using a radioactive label, it was established that the drug rapidly enters the bloodstream from the gastrointestinal tract. Evenly raspredepyaetsya to internal organs. The maximum blood concentration, blood and most organs plasma reached 30 minutes after administration. At the same time the quality characteristics of pharmacokinetic curves go to sleep each injection were identical: a rapid rise buy proviron in drug concentration after each injection and then a slow decline to 24 hours.
The drug is not metabolized in the body and is excreted unchanged.
The main elimination process takes place within 24 hours. During this period, output 80% of the administered dose: 34.8% is excreted in the time interval from 0 to 5 hours and 45.2% in the time interval from 5 to 24 chaso. Of which 77% is excreted through the intestines and 23% – in the kidney.
Treatment of influenza. If necessary, combine with the reception of symptomatic drugs
Hypersensitivity of the components of the preparation. Pregnancy. Children under 18 years old.
Pregnancy and lactation
Use of the drug during pregnancy has not been studied. Use of the drug during lactation has not been studied, therefore buy proviron breast-feeding should be discontinued, if necessary, use during lactation.
Dosing and Administration
Inside, regardless of meals.
At 90 mg 1 time per day, 5 days.
The drug starts with the appearance of the first symptoms of the disease, not later than 36 hours from the onset of the disease.
Allergic reactions (rare).
Cases of overdose have not been described.
Interaction with other drugs.
Cases Ingavirin ® interaction with other drugs have been identified.
The drug does not have a sedative effect, does not affect the speed of psychomotor reactions and can be used in people of different professions, including requiring attention and coordination. Not recommended simultaneous reception of other buy proviron antiviral drugs.
capsules, 30 mg and 90 mg. On 7 capsules in blisters of PVC film and aluminum foil printed patent. On 90 capsules (for a dosage of 30 mg) or 60 capsules (for a dosage of 90 mg) in polymeric jars complete with lids (for hospitals). One contour package together with instructions for use placed in a pack. Banks are placed in a box made of cardboard with the application instructions on the application (for hospitals).
In a dry place, protected from light and the reach of children at or above 25 ° C.
2 years. Do not use beyond the buy proviron expiration date.